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Thymosin in cancer patients: in vitro effects and correlations with clinical response to thymosin immunotherapy.

Abstract
Studies on the effect of thymosin on T-cell levels in vitro among normal persons and cancer patients show that, in general, T-cell levels increase after incubation with thymosin in populations with low initial T-cell levels while the levels decrease in populations with high initial T-cell levels. In patients with small cell carcinoma of the lung receiving intensive chemotherapy also randomized to receive thymosin at a dose of 60 mg/m2, thymosin at a dose of 20 mg/m2, or placebo twice weekly, increased survival occurred in patients receiving the thymosin dose of 60 mg/m2. The increase in survival was greatest in patients with low pretreatment T-cell and alpha2HS-glycoprotein levels. These observations suggest that the cancer patients most likely to benefit therapeutically from adjuvant treatment with thymosin are those with relatively low initial T-cell levels and other parameters of cellular immunity.
AuthorsP B Chretien, S D Lipson, R Makuch, D E Kenady, M H Cohen, J D Minna
JournalCancer treatment reports (Cancer Treat Rep) Vol. 62 Issue 11 Pg. 1787-90 (Nov 1978) ISSN: 0361-5960 [Print] United States
PMID215307 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Glycoproteins
  • Thymus Hormones
  • Thymosin
Topics
  • Carcinoma, Small Cell (blood, drug therapy, immunology)
  • Clinical Trials as Topic
  • Glycoproteins (blood)
  • Humans
  • Immunity, Cellular (drug effects)
  • In Vitro Techniques
  • Leukocyte Count
  • Lung Neoplasms (blood, drug therapy, immunology)
  • T-Lymphocytes (drug effects)
  • Thymosin (pharmacology)
  • Thymus Hormones (pharmacology)

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