Abstract | OBJECTIVE: SAMPLE: PROCEDURES: RESULTS: The addition of ENL or END with melatonin to cAMP-stimulated cells (treated cells) resulted in significant decreases in estradiol, androstenedione, and cortisol concentrations at 24 and 48 hours, compared with concentrations in cells stimulated with cAMP alone (cAMP control cells). The addition of these compounds to cAMP-stimulated cells also resulted in higher progesterone and 17-hydroxyprogesterone concentrations than in cAMP control cells; aldosterone concentration was not affected by treatments. Compared with the content in cAMP control cells, aromatase content in treated cells was significantly lower. CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Kellie A Fecteau, Hugo Eiler, Jack W Oliver |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 72
Issue 5
Pg. 675-80
(May 2011)
ISSN: 1943-5681 [Electronic] United States |
PMID | 21529220
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lignans
- Phytoestrogens
- Steroids
- 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol
- Cyclic AMP
- Aromatase
- Melatonin
- 4-Butyrolactone
- 2,3-bis(3'-hydroxybenzyl)butyrolactone
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Topics |
- 4-Butyrolactone
(analogs & derivatives, pharmacology)
- Adrenal Glands
(drug effects, metabolism)
- Animals
- Aromatase
(metabolism)
- Cell Line
- Cyclic AMP
(metabolism)
- Dogs
- Humans
- Lignans
(pharmacology)
- Melatonin
(pharmacology)
- Phytoestrogens
(pharmacology)
- Steroids
(analysis, biosynthesis)
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