Efficacy of tube feeding in binge-eating/vomiting patients: a 2-month randomized trial with 1-year follow-up.

Abstract

BACKGROUND:

In many binge-eating/vomiting patients, abstinence could not be obtained from classical treatments. Since the authors showed that tube feeding (TF) reduced such episodes in anorexia nervosa (AN)-hospitalized patients, they carried out a randomized trial on the efficacy of TF plus cognitive behavioral therapy (CBT) vs CBT alone in AN and bulimia nervosa adult outpatients.

METHODS:

The authors randomly assigned 103 ambulatory patients to receive 16 sessions of CBT alone (n = 51) or CBT plus 2 months of TF (n = 52). The main goal was abstinence of binge-eating/vomiting episodes. Other criteria were gains in fat-free mass and muscle mass improvements in nutrition markers, and quality of life (SF-36 Health Survey), depression (Beck Depression Inventory), and anxiety (Hamilton Anxiety Rating Scale) scores. Evaluations were performed at 1, 2 (end of treatment), 5, 8, and 14 months (analysis of variance).

RESULTS:

TF patients were rapidly and more frequently abstinent at the end of treatment (2 months) than the CBT patients: 81% vs 29% (P < .001). Fat-free mass, biological markers, depressive state (-58% vs -26%), anxiety (-48% vs -15%), and quality of life (+42% vs +13%) were more improved in the TF group than in the CBT group (P < .05). One year later, more TF patients remained abstinent (68% vs 27%, P = .02); they were less anxious, were less depressed, and had better quality of life than the CBT patients (P < .05).

CONCLUSION:

TF combined with CBT offered better results than CBT alone.

• Authors: Daniel Jacques Rigaud, Véronique Brayer, Anne Roblot, Marie-Claude Brindisi, Bruno Vergès
• Journal: JPEN. Journal of parenteral and enteral nutrition (JPEN J Parenter Enteral Nutr) Vol. 35 Issue 3 Pg. 356-64 (May 2011) ISSN: 1941-2444 [Electronic] United States
• PMID: 21527597 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers

Topics

• Adult
• Anxiety
• Biomarkers (analysis)
• Body Fluid Compartments
• Bulimia (psychology, therapy)
• Bulimia Nervosa (psychology, therapy)
• Cognitive Behavioral Therapy
• Depression
• Enteral Nutrition
• Humans
• Muscle, Skeletal
• Quality of Life
• Treatment Outcome
• Vomiting (epidemiology, psychology, therapy)
• Young Adult