Abstract | BACKGROUND: MATERIAL AND METHODS: This prospective, randomized, double blind, placebo controlled study was done in 200 patients undergoing elective surgery requiring dexamethasone. The patients were randomized into two groups of 100 each. Group BD received 5 ml normal saline followed, 5 minutes later, by 8 mg dexamethasone bolus intravenously. Group FD received 1 microg/kg fentanyl diluted in saline to a volume of 5 ml followed by 8 mg dexamethasone bolus 5 minutes later. The time of onset, intensity, site, duration and nature of the pain after the drug administration were recorded. RESULTS: The demographic profile was comparable in the two groups. The incidence and severity of pain was more in females as compared to males (p value = 0). The pain was located especially in the perineal region and was expressed as itching (62%), burning (13%) or both (25%). The incidence of pain, its duration and severity were significantly reduced after pretreatment with fentanyl (p value = 0). DISCUSSION:
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Authors | Vimi Rewari, Rakesh Garg, Anjan Trikha, Chandralekha |
Journal | Middle East journal of anaesthesiology
(Middle East J Anaesthesiol)
Vol. 20
Issue 6
Pg. 803-8
(Oct 2010)
ISSN: 0544-0440 [Print] Lebanon |
PMID | 21526664
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Glucocorticoids
- dexamethasone 21-phosphate
- Sodium Chloride
- Dexamethasone
- Fentanyl
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Topics |
- Adult
- Analgesics, Opioid
(therapeutic use)
- Dexamethasone
(administration & dosage, adverse effects, analogs & derivatives)
- Double-Blind Method
- Female
- Fentanyl
(administration & dosage)
- Glucocorticoids
(administration & dosage, adverse effects)
- Humans
- Male
- Pain
(chemically induced, prevention & control)
- Pain Measurement
(methods)
- Perineum
- Premedication
- Prospective Studies
- Pruritus
(chemically induced, prevention & control)
- Severity of Illness Index
- Sex Distribution
- Sodium Chloride
(administration & dosage)
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