The protective role of Lychnophora ericoides Mart. (Brazilian arnica) in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.

Abstract

Aberrant crypt foci (ACF) and colon rectal mucosal epithelial cell proliferation have been shown to be increased in patients with colon cancer and have been largely used for early detection of factors that influence colorectal carcinogenesis in rats. Fifty male Wistar rats were randomly divided into 5 groups. The groups G1 to G4 were given 4 injections of the carcinogen 1,2-dimethylhydrazine (DMH). The G2 group received Lychnophora ericoides (LE) extracts for 6 wk. The groups G3 and G4 received LE for 4 wk and 2 wk, respectively, at the postinitiation and initiation phases of colonic carcinogenesis. The group G5 was the control. Forty-two days after the first injections of DMH for the neoplasic induction, we observed a statistically significant decrease in the number of aberrant crypt foci (ACF) and an attenuation of the increase in cell proliferation induced by DMH in all the LE-treated groups. Thus, we concluded that Lychnophora ericoides extracts were effective against the development of cancer. These data suggest that LE has a protective influence on the process of colon carcinogenesis, suppressing both the initiation and the promotion of colonic carcinogenesis.

• Authors: Cleverson Rodrigues Fernandes, Aline Turatti, Dayana Rubio Gouvea, Leonardo Gobbo-Neto, Andrea Diniz, Alfredo Ribeiro-Silva, Norberto Peporine Lopes, Sérgio Britto Garcia
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 63 Issue 4 Pg. 593-9 ( 2011) ISSN: 1532-7914 [Electronic] United States
• PMID: 21526453 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Anticarcinogenic Agents
• Carcinogens
• Plant Extracts
• Cyclooxygenase 2
• Ptgs2 protein, rat
• 1,2-Dimethylhydrazine

Topics

• 1,2-Dimethylhydrazine (toxicity)
• Aberrant Crypt Foci (chemically induced, drug therapy)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Anticarcinogenic Agents (pharmacology)
• Arnica (chemistry)
• Carcinogens (toxicity)
• Cell Proliferation
• Chromatography, High Pressure Liquid
• Colonic Neoplasms (chemically induced, drug therapy)
• Cyclooxygenase 2 (genetics, metabolism)
• Intestinal Mucosa
• Male
• Neoplasms, Experimental (chemically induced, drug therapy)
• Phytotherapy
• Plant Extracts (pharmacology)
• Precancerous Conditions
• Rats
• Rats, Wistar