Abstract | OBJECTIVE: BACKGROUND:
Bariatric surgery is currently considered the most effective treatment for morbid obesity and its comorbidities; however, a systematic study of their mechanisms is still lacking. METHODS: RESULTS: All bariatric surgeries resulted in significant weight loss, reduced body fat and improved glucose tolerance in the short term (4 weeks), compared with mice with sham surgery. Of the bariatric surgery models, sleeve gastrectomy and mRYGB had higher success rates and lower mortalities and represent reliable restrictive and gastrointestinal (GI) bypass mouse bariatric surgery models, respectively. In the long term, the GI bypass procedure produced more profound weight loss, significant improvement of glucose tolerance and liver steatosis than the restrictive procedure. DIO mice had increased insulin promoter activity, suggesting overactivation of pancreatic beta cells, which was regulated by the mRYGB procedure. Compared with the restrictive procedure, the GI bypass procedure showed more severe symptoms of malnutrition following bariatric surgery. DISCUSSIONS: Both restrictive and GI bypass procedures provide positive effects on weight loss, fat composition, liver steatosis and glucose tolerance; however, in the long term, the GI bypass shows better results than restrictive procedures.
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Authors | Deng Ping Yin, Qiang Gao, Lian Li Ma, Wenwei Yan, Phillip E Williams, Owen P McGuinness, David H Wasserman, Naji N Abumrad |
Journal | Annals of surgery
(Ann Surg)
Vol. 254
Issue 1
Pg. 73-82
(Jul 2011)
ISSN: 1528-1140 [Electronic] United States |
PMID | 21522012
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Bariatric Surgery
(methods)
- Disease Models, Animal
- Feasibility Studies
- Insulin Resistance
- Mice
- Mice, Inbred C57BL
- Obesity
(surgery)
- Time Factors
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