Abstract |
At present cancer treatment is still a confusing problem. Great progress has been made in anti- tumor agents since a series of small molecules are approved by FDA as anti- tumor drugs. Nitroimidazoles is a kind of radiosensitizer with multiple bioactivities used in cancer treatment since 1950s. In this review, we focus on the development of nitroimidazoles as radiosensitizer, bio-reductive prodrug and other types of anti- tumor agents for cancer therapy, and the mechanism of acting as anti- tumor agents. Finally, we also discuss the prospect and developmental trend of nitroimidazoles as anti- tumor agents.
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Authors | Kai Liu, Hai-Liang Zhu |
Journal | Anti-cancer agents in medicinal chemistry
(Anticancer Agents Med Chem)
Vol. 11
Issue 7
Pg. 687-91
(Sep 2011)
ISSN: 1875-5992 [Electronic] Netherlands |
PMID | 21521156
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antineoplastic Agents
- Nitroimidazoles
- Prodrugs
- Radiation-Sensitizing Agents
- Oxygen
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, metabolism, pharmacology)
- Biotransformation
- Humans
- Hypoxia
(metabolism)
- Neoplasms
(drug therapy, pathology, radiotherapy)
- Nitroimidazoles
(chemistry, metabolism, pharmacology)
- Oxidation-Reduction
- Oxygen
(metabolism)
- Prodrugs
(chemistry, metabolism, pharmacology)
- Radiation-Sensitizing Agents
(chemistry, metabolism, pharmacology)
- Tumor Cells, Cultured
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