PPAR-alpha in cutaneous inflammation.

Abstract

Peroxisome proliferator-activated receptor (PPAR)-alpha is a fatty acid activated transcription factors that belongs to the nuclear hormone receptor family. Primarily PPAR-alpha serves as a lipid sensor. While PPAR-alpha controls enzymes from the lipid and glucose metabolism in the liver, heart and muscles, PPAR-alpha is also involved in skin homeostasis. PPAR-alpha controls keratinocyte proliferation/differentiation, contributes to wound healing and regulates skin inflammation. PPAR-alpha activation exerts anti-inflammatory effects in various skin conditions such as irritant and allergic contact dermatitis, atopic dermatitis and UV-induced erythema, rendering investigations into the functions of PPAR-alpha necessary to provide better understandings to treat many inflammatory skin disorders.

• Authors: Sandrine Dubrac, Matthias Schmuth
• Journal: Dermato-endocrinology (Dermatoendocrinol) Vol. 3 Issue 1 Pg. 23-6 (Jan 2011) ISSN: 1938-1980 [Electronic] United States
• PMID: 21519405 (Publication Type: Journal Article)