Abstract | AIM: METHODS: RESULTS: Post-meal, the prandial + basal insulin group had significantly higher insulin, lower glucose and triglycerides, as well as lower high-sensitivity C-reactive protein, tumour necrosis factor α and interleukin-6, than the basal insulin group. Glucose incremental area under the concentration curve significantly correlated with high-sensitivity C-reactive protein, tumour necrosis factor α, interleukin-6, methylglyoxal and 3-deoxyglucosone incremental area under the concentration curve. Insulin incremental area under the concentration curve correlated inversely with high-sensitivity C-reactive protein and tumour necrosis factor α incremental area under the concentration curve. However, after adjusting for glucose incremental area under the concentration curve, these inverse correlations were no longer significant. Triglyceride incremental area under the concentration curve was not correlated with any biomarker incremental area under the concentration curve. CONCLUSIONS:
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Authors | P J Beisswenger, W V Brown, A Ceriello, N A Le, R B Goldberg, J P Cooke, D C Robbins, S Sarwat, H Yuan, C A Jones, M H Tan, IOOI Study Investigators |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 28
Issue 9
Pg. 1088-95
(Sep 2011)
ISSN: 1464-5491 [Electronic] England |
PMID | 21517955
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK. |
Chemical References |
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
- Insulin, Long-Acting
- Interleukin-6
- Tumor Necrosis Factor-alpha
- C-Reactive Protein
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Topics |
- Adult
- Aged
- C-Reactive Protein
(metabolism)
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Female
- Glycated Hemoglobin
- Humans
- Hyperglycemia
(drug therapy, metabolism)
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Insulin
(analogs & derivatives, pharmacology, therapeutic use)
- Insulin, Long-Acting
- Interleukin-6
(metabolism)
- Male
- Middle Aged
- Postprandial Period
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(metabolism)
- United States
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