Efficacy of hypolipidemic treatment in inhibition of experimental atherosclerosis: the effect of nicotinic acid and related compounds.

Abstract

The hypolipidemic and antiatherogenic effects of different nicotinic acid derivatives were studied. Five rabbit groups maintained on an atherogenic diet were given simultaneously various nicotinic acid derivatives (50 mg/kg body weight/day): nicotinic acid, Xantinol-nicotinate, beta-pyridylcarbinol or Pirozadil (bis-3,4,5-trimethoxybenzoate, 2,6-pyridindiyldimethylene). All 4 compounds showed a clear hypocholesterolemic and antiatherogenic effect, as measured by serum cholesterol, and by planimetric evaluation of the aortic lesions in terms of percent surface area affected in the aortas and coronary lumen. The simultaneously observed elevation of the HDL/LDL cholesterol ratio of the aortic tissue possibly indicates an antiatherogenic effect of these changes.

• Authors: M R Parwaresch, H Haacke, C Mäder
• Journal: Atherosclerosis (Atherosclerosis) Vol. 31 Issue 4 Pg. 395-401 (Dec 1978) ISSN: 0021-9150 [Print] Ireland
• PMID: 215172 (Publication Type: Journal Article)

Chemical References

• Cholesterol Esters
• Lipoproteins, LDL
• Nicotinic Acids
• Pyridines
• pirozadil
• Gallic Acid
• Xanthinol Niacinate
• Cholesterol
• Nicotinyl Alcohol

Topics

• Animals
• Aorta (metabolism, pathology)
• Arteriosclerosis (blood, pathology, prevention & control)
• Cholesterol (blood)
• Cholesterol Esters (blood)
• Coronary Vessels (metabolism)
• Diet, Atherogenic
• Gallic Acid (analogs & derivatives, therapeutic use)
• Lipoproteins, LDL (blood)
• Male
• Nicotinic Acids (therapeutic use)
• Nicotinyl Alcohol (therapeutic use)
• Pyridines (therapeutic use)
• Rabbits
• Xanthinol Niacinate (therapeutic use)