[Effects of indenolol on left ventricular mass in patients with essential arterial hypertension].
|
| Abstract |
This study evaluated the effect of long-term antihypertensive therapy with indenolol, a beta blocking agent with beta 2 stimulating activity, its antihypertensive hemodynamic mechanism and its effect on hypertensive left ventricular (LV) hypertrophy. Fourteen hypertensive patients, mean age of 48 years, were serially studied during 12- month therapy with indenolol (60-120 mg daily), by recording blood pressure, electrocardiogram and echocardiogram. Blood pressure, heart rate and cardiac output significantly decreased after 1 months of therapy, LV posterior wall thickness decreased after 6 months, interventricular septum thickness and LV mass decreased after 12 months. LV fractional shortening did not change throughout the study. Blood pressure normalized (less than or equal to 140/90 mmHg) in 50% of the patients; LV mass normalized in 40% of the patients. In conclusion, indenolol was an effective antihypertensive agent, also in the long-term treatment. Its antihypertensive hemodynamic effect seems to be due mainly to a reduction in cardiac output. Indenolol caused a regression of LV hypertensive hypertrophy without impairment of LV systolic function.
|
|---|---|
| Authors | F Sau, C Seguro, C Lai, E Orani, A Soro, E Onnis, A Cherchi |
| Journal | Cardiologia (Rome, Italy) (Cardiologia) Vol. 35 Issue 11 Pg. 925-30 (Nov 1990) ISSN: 0393-1978 [Print] Italy |
| Vernacular Title | Effetti dell'indenololo sulla massa ventricolare sinistra nei pazienti affetti da ipertensione arteriosa essenziale. |
| PMID | 2151570 (Publication Type: English Abstract, Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!