Impact of bleeding on subsequent early and late mortality after drug-eluting stent implantation.

Abstract

OBJECTIVES:

The aim of this study was to assess the impact of early and late bleeding on subsequent mortality after drug-eluting stent (DES) implantation.

BACKGROUND:

Little is known about the impact of late bleeding after DES implantation.

METHODS:

With a time-updated Cox model, the impact of bleeding and myocardial infarction (MI) on 3-year mortality was analyzed in 3,148 consecutive patients who underwent DES implantation for coronary disease.

RESULTS:

Bleeding, defined according to STEEPLE (Safety and Efficacy of Enoxaparin in PCI Patients, an International Randomized Evaluation) minor or major criteria, occurred in 6.5% of patients over 3 years. Patients with bleeding were older; were more likely to be female; had higher rates of diabetes mellitus, hypertension, and extensive coronary disease and lower ventricular function; and underwent more complex procedures than those without bleeding. The 3-year adjusted hazard ratios (HRs) for mortality were 5.81 (95% confidence interval [CI]: 3.92 to 8.60; p < 0.001) for patients with bleeding and 2.53 (95% CI: 1.62 to 3.96; p < 0.001) for patients with MI. When the timings of events were separated, the HRs for mortality were 4.89 (95% CI: 3.08 to 7.78; p < 0.001) and 7.81 (95% CI: 4.39 to 13.89; p < 0.001) for patients with bleeding within and after 30 days, respectively. By contrast, the HRs for mortality were 1.85 (95% CI: 1.09 to 3.14, p = 0.022) and 10.33 (95% CI: 4.91 to 21.75, p < 0.001) for patients with MI within and after 30 days, respectively.

CONCLUSIONS:

Bleeding is closely associated with mortality during both the early and late periods after DES implantation. Therefore, in addition to carefully assessing bleeding after stenting, evidence-based treatment should be implemented to offer the best balance of benefit and harm.

• Authors: Young-Hak Kim, Jong-Young Lee, Jung-Min Ahn, Haegeun Song, Won-Jang Kim, Sung-Cheol Yun, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
• Journal: JACC. Cardiovascular interventions (JACC Cardiovasc Interv) Vol. 4 Issue 4 Pg. 423-31 (Apr 2011) ISSN: 1876-7605 [Electronic] United States
• PMID: 21511222 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Topics

• Aged
• Angioplasty, Balloon, Coronary (adverse effects, instrumentation, mortality)
• Coronary Disease (mortality, therapy)
• Drug-Eluting Stents
• Female
• Hemorrhage (etiology, mortality)
• Hospital Mortality
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Myocardial Infarction (etiology, mortality)
• Proportional Hazards Models
• Registries
• Republic of Korea
• Risk Assessment
• Risk Factors
• Time Factors
• Treatment Outcome