Abstract | AIMS OF THE STUDY: MATERIALS AND METHODS: RESULTS: OWV showed anti-inflammatory effects on DNCB-induced dermatitis in mice, leading to inhibition of IgE production, immune cell infiltration, and iNOS expression. Skin thickness and the level of phospho-STAT3 were dramatically reduced by OWV. Using the HaCaT human keratinocyte cell line, we confirmed that constitutive STAT3 activation induced faster proliferation of epithelial cells. In addition, OWV suppressed HaCaT proliferative ability and phospho-STAT3 levels. CONCLUSIONS: The study revealed that OWV has anti-inflammatory and anti-proliferative effects in a DNCB-induced contact dermatitis mice model. Furthermore, we showed that the mechanism by which OWV most likely inhibits epithelial proliferation is through STAT3 inactivation.
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Authors | Chang Seok Lee, Eun Hee Yi, Hang-Rae Kim, Sang-Rok Huh, Sang-Hyun Sung, Myung-Hee Chung, Sang-Kyu Ye |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 135
Issue 3
Pg. 747-53
(Jun 01 2011)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 21511023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Dinitrochlorobenzene
- Plant Preparations
- STAT3 Transcription Factor
- Immunoglobulin E
- Nitric Oxide Synthase Type II
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Cell Line
- Cell Proliferation
(drug effects)
- Dermatitis, Allergic Contact
(metabolism, pathology, prevention & control)
- Dinitrochlorobenzene
- Disease Models, Animal
- Female
- Humans
- Immune System Phenomena
(drug effects)
- Immunoglobulin E
(biosynthesis)
- Keratinocytes
(drug effects, metabolism, pathology)
- Mice
- Mice, Inbred BALB C
- Nitric Oxide Synthase Type II
(metabolism)
- Phytotherapy
- Plant Preparations
(pharmacology, therapeutic use)
- Quercus
- STAT3 Transcription Factor
(antagonists & inhibitors)
- Skin
(drug effects, metabolism, pathology)
- Wood
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