Neuropeptide converting enzyme activities in CSF of low back pain patients.

Abstract

The activity levels of a dynorphin converting enzyme (DCE), a substance P endopeptidase (SPE) and a substance P alpha-amidating enzyme (SP-GLYE) were measured in the cerebrospinal fluid (CSF) of 90 patients with chronic low back pain, sciatica and neurological signs of rhizopathy. The DCE activity was significantly higher in men than in women. Age was related to the DCE activity independent of sex, i.e., older patients had higher enzyme activity. The activities of two substance P converting enzymes were not related to sex or age. Self-reported pain experience and affective covariates (anxiety, depression, hostility, somatization) of pain, and myelography data were not found to be related to the enzyme activity levels once adjustment had been made for sex and age. The activity levels of the enzymes measured here had no predictive value for the long-term outcome of rehabilitation and therapy at the 5-year follow-up of the patients. The sex difference in DCE activity provides further evidence in favor of the role of gender in the psychoendocrine coping with pain distress.

• Authors: Markku T Hyyppä, Hannu Alaranta, Kari Lahtela, Finn Nykvist, Matti Hurme, Fred Nyberg, Pierre Le Grevés, Tsukasa Sakurada, Lars Terenius
• Journal: Pain (Pain) Vol. 43 Issue 2 Pg. 163-168 (Nov 1990) ISSN: 0304-3959 [Print] United States
• PMID: 2150878 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Multienzyme Complexes
• Mixed Function Oxygenases
• peptidylglycine monooxygenase
• Cysteine Endopeptidases
• dynorphin converting enzyme
• Metalloendopeptidases
• substance P degrading enzyme

Topics

• Adult
• Back Pain (cerebrospinal fluid)
• Cysteine Endopeptidases (cerebrospinal fluid)
• Humans
• Metalloendopeptidases (cerebrospinal fluid)
• Middle Aged
• Mixed Function Oxygenases (cerebrospinal fluid)
• Multienzyme Complexes
• Regression Analysis
• Sex Factors