[Intravitreal bevacizumab treatment for choroidal neovascularization in Best's disease].

Abstract

Best's disease is an autosomal-dominant macular dystrophy, which might lead to choroidal neovascularization. The case of a 9-year-old boy followed up for a Best's disease is hereby reported. The boy was referred to our service department for a decrease in visual acuity in his right eye. Ophthalmoscopic examination revealed a foveolar vitelliform lesion, complicated by a choroidal neovascularization. The patient received a single intravitreal bevacizumab injection, which led to a complete resolution of intraretinal fluid and a significant reduction in neovascularization size. Visual acuity also improved. This case underlines the efficiency efficacy of intravitreal anti-VEGF therapy for choroidal neovascularization in Best's disease.

• Authors: J Perol, B Wolff, J-A Sahel, Y Le Mer
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 34 Issue 5 Pg. 281-6 (May 2011) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Traitement par injection intravitréenne de bevacizumab de néovaisseaux choroïdiens compliquant une maladie de Best.
• PMID: 21507509 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Bevacizumab

Topics

• Angiogenesis Inhibitors (administration & dosage, therapeutic use)
• Antibodies, Monoclonal (administration & dosage, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Bevacizumab
• Child
• Choroidal Neovascularization (diagnostic imaging, drug therapy, etiology)
• Fluorescein Angiography
• Genes, Dominant
• Humans
• Intravitreal Injections
• Male
• Pedigree
• Radiography
• Retinal Detachment (etiology)
• Retinal Hemorrhage (etiology)
• Tomography, Optical Coherence
• Visual Acuity
• Vitelliform Macular Dystrophy (complications, genetics)