Effects of antioxidant polyphenols on TNF-alpha-related diseases.

Abstract

Oxidative stress and inflammatory responses sustained for a long period of time cause many diseases. A proinflammatory cytokine, tumor necrosis factor α (TNF-α), plays a pivotal role in the pathogenesis of chronic and auto-immune diseases. The present review, supplemented by hitherto unpublished data of the authors and their coworkers, shows that the intake of polyphenols contained in natural sources, such as hydroxytyrosol, tyrosol, oleuropein (olives), naringin and hesperidin (Citrus fruits), resveratrol, procyanidins or oligomeric procyanidin (grapes or grape seed extracts), (-)-epigallocatechin gallate (green tea) and quercetin (grapes, green tea) etc., are able to modulate chronic inflammatory diseases, such as type 2 diabetes, rheumatoid arthritis, inflammatory bowel disease, and affect the formation and interaction of advanced glycation end products with their respective receptors. Furthermore, potent activities of fermented grape marc, prepared as a fine lyophilized powder from fresh skin and seeds of a Japanese grape strain (Koshu) and then fermented with Lactobacillus plantarum, are described. Finally, the bioavailability of representative polyphenols will be discussed.

• Authors: Kiichiro Kawaguchi, Tsukasa Matsumoto, Yoshio Kumazawa
• Journal: Current topics in medicinal chemistry (Curr Top Med Chem) Vol. 11 Issue 14 Pg. 1767-79 ( 2011) ISSN: 1873-4294 [Electronic] United Arab Emirates
• PMID: 21506932 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antioxidants
• Flavonoids
• Glycation End Products, Advanced
• Phenols
• Plant Extracts
• Polyphenols
• Tea
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Antioxidants (pharmacokinetics, therapeutic use)
• Arthritis, Rheumatoid (drug therapy, physiopathology)
• Biological Availability
• Diabetes Mellitus, Type 2 (drug therapy, physiopathology)
• Fermentation
• Flavonoids (pharmacology)
• Glycation End Products, Advanced (antagonists & inhibitors, biosynthesis)
• Humans
• Inflammatory Bowel Diseases (drug therapy, physiopathology)
• Lactobacillus plantarum (metabolism)
• Mice
• Oxidative Stress
• Phenols (pharmacology)
• Plant Extracts (pharmacology, therapeutic use)
• Polyphenols
• Rats
• Seeds (chemistry)
• Tea (chemistry)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, biosynthesis)
• Vitis (chemistry)