Early plasmapheresis followed by high-dose γ-globulin treatment saved a severely Rho-incompatible pregnancy.

Abstract

An alloimmunized pregnancy induces anemia in the fetus and can ultimately lead to fetal hydrops and intrauterine fetal death. A woman with a severe Rho-incompatible pregnancy had experienced frequent pregnancies with fetomaternal transfusion without receiving RhIg and had high anti-D antibody titers present from early pregnancy. We succeeded in long-term inhibition of antibody production using plasmapheresis followed by high-dose γ-globulin treatment in early pregnancy.

• Authors: Sakiko Isojima, Michi Hisano, Teruaki Suzuki, Haruhiko Sago, Atsuko Murashima, Koushi Yamaguchi
• Journal: Journal of clinical apheresis (J Clin Apher) Vol. 26 Issue 4 Pg. 216-8 ( 2011) ISSN: 1098-1101 [Electronic] United States
• PMID: 21506141 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Wiley-Liss, Inc.

Chemical References

• Immunoglobulins, Intravenous
• Isoantibodies
• Rh-Hr Blood-Group System
• Rho(D) Immune Globulin

Topics

• Adult
• Erythroblastosis, Fetal (immunology, therapy)
• Exchange Transfusion, Whole Blood
• Female
• Humans
• Immunoglobulins, Intravenous (administration & dosage)
• Infant, Newborn
• Isoantibodies (blood)
• Male
• Plasmapheresis
• Pregnancy
• Pregnancy Complications, Hematologic (immunology, therapy)
• Rh Isoimmunization (immunology, therapy)
• Rh-Hr Blood-Group System (immunology)
• Rho(D) Immune Globulin (administration & dosage)