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T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients.

Abstract
A 'vascular normalization index' (VNI) based on the changes in the magnetic resonance imaging (MRI) parameters K(trans) and cerebral blood volume (CBV), combined with blood sampling, has been shown to correlate with patient outcome in recurrent glioblastoma after a single dose of antiangiogenic therapy. Here, by applying a novel contrast agent extravasation correction method insensitive to variations in tissue mean transit time, we show that a similar VNI parameter can be derived from a single dynamic susceptibility contrast MR acquisition rather than the three parameters shown previously. Our results show that this new VNI parameter, which combines changes in tumoral CBV and an apparent transfer constant from our leakage correction method, may provide prognostic information in an even simpler manner than prior efforts.
AuthorsKyrre E Emblem, Atle Bjornerud, Kim Mouridsen, Ronald J H Borra, Tracy T Batchelor, Rakesh K Jain, A Gregory Sorensen
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 31 Issue 10 Pg. 2054-64 (Oct 2011) ISSN: 1559-7016 [Electronic] United States
PMID21505476 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiogenesis Inhibitors
  • Contrast Media
  • Quinazolines
  • cediranib
Topics
  • Angiogenesis Inhibitors (administration & dosage)
  • Brain Neoplasms (diagnostic imaging, drug therapy, mortality, physiopathology)
  • Contrast Media (administration & dosage)
  • Disease-Free Survival
  • Female
  • Glioblastoma (diagnostic imaging, drug therapy, mortality, physiopathology)
  • Humans
  • Magnetic Resonance Angiography (methods)
  • Male
  • Quinazolines (administration & dosage)
  • Radiography
  • Survival Rate

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