Abstract | BACKGROUND: Reports of positive patch test and photopatch test reactions to the chemical ultraviolet filter octocrylene have increased during the last decade. Little is known about the reason for octocrylene's allergenic activity. OBJECTIVES: To present and discuss the results of patch tests and photopatch tests with octocrylene, and to investigate the possible cause of its allergenic properties. METHODS: Results of patch tests and photopatch tests with octocrylene in patients with adverse skin reactions to sunscreen products and/or ketoprofen were collected. The allergenic potency of octocrylene was investigated in the murine local lymph node assay (LLNA). Chemical reactivity assays were used to mimic octocrylene's interaction with biomolecules. RESULTS: CONCLUSIONS:
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Authors | Isabella Karlsson, Katrien Vanden Broecke, Jerker Mårtensson, An Goossens, Anna Börje |
Journal | Contact dermatitis
(Contact Dermatitis)
Vol. 64
Issue 6
Pg. 343-52
(Jun 2011)
ISSN: 1600-0536 [Electronic] England |
PMID | 21504434
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Acrylates
- Benzophenones
- Sunscreening Agents
- octocrylene
- Ketoprofen
- oxybenzone
- Lysine
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Topics |
- Acrylates
(adverse effects, metabolism)
- Adult
- Aged
- Animals
- Benzophenones
(adverse effects)
- Child
- Child, Preschool
- Dermatitis, Allergic Contact
(etiology)
- Dermatitis, Photoallergic
(etiology)
- Female
- Humans
- Ketoprofen
(adverse effects)
- Local Lymph Node Assay
- Lysine
(metabolism)
- Male
- Mice
- Middle Aged
- Patch Tests
(methods)
- Skin
(metabolism)
- Sunscreening Agents
(adverse effects)
- Young Adult
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