Abstract | BACKGROUND: METHODS: This is a prospective, three-armed, randomized controlled trial of 79 patients in the neurology/neurosurgery intensive care unit (NNICU) of a tertiary care academic hospital. Eligible patients who developed a temperature ≥38°C were randomized to receive either a single dose of APAP 975 mg, a single dose of IBU 800 mg, or a combination of both (APAP + IBU). Oral temperatures were measured hourly for 6 h following medication administration. RESULTS: All three treatments decreased temperature over the 6-h period. The area under the curve (AUC) for ΔT for APAP was -3.55°C-h (95% CI -4.75 to -2.34°C-h); for IBU was -4.05°C-h (95% CI -5.16 to -2.94°C-h); and for the combination of APAP and IBU was -5.10°C-h (95% CI -6.20 to -4.01°C-h). The differences in AUC between the groups were as follows: IBU versus APAP = -0.50°C-h (P = 0.28), APAP + IBU versus IBU = -1.05°C-h (P = 0.09), and APAP + IBU versus APAP = -1.56°C-h (P = 0.03). CONCLUSION: The combination of IBU and APAP produces significantly greater fever control than APAP alone, with trends favoring the combination over IBU alone and IBU over APAP alone.
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Authors | Michael E Mullins, Matthew Empey, David Jaramillo, Sameta Sosa, Theresa Human, Michael N Diringer |
Journal | Neurocritical care
(Neurocrit Care)
Vol. 15
Issue 3
Pg. 375-8
(Dec 2011)
ISSN: 1556-0961 [Electronic] United States |
PMID | 21503807
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antipyretics
- Acetaminophen
- Ibuprofen
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Topics |
- Academic Medical Centers
- Acetaminophen
(administration & dosage, adverse effects)
- Antipyretics
(administration & dosage, adverse effects)
- Body Temperature
(drug effects)
- Drug Therapy, Combination
- Fever
(drug therapy)
- Humans
- Ibuprofen
(administration & dosage, adverse effects)
- Intensive Care Units
- Intracranial Hemorrhages
(complications, etiology, therapy)
- Prospective Studies
- Thermometers
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