Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors.

Abstract

PURPOSE:

Thymic epithelial tumors are rare malignancies, and there is no standard treatment for patients with advanced disease in whom chemotherapy has failed. Antitumor activity of histone deacetylase (HDAC) inhibitors in this disease has been documented, including one patient with thymoma treated with the pan-HDAC inhibitor belinostat.

PATIENTS AND METHODS:

Patients with advanced thymic epithelial malignancies in whom at least one line of platinum-containing chemotherapy had failed were eligible for this study. Other eligibility criteria included adequate organ function and good performance status. Belinostat was administered intravenously at 1 g/m(2) on days 1 to 5 of a 21-day cycle until disease progression or development of intolerance. The primary objective was response rate in patients with thymoma.

RESULTS:

Of the 41 patients enrolled, 25 had thymoma, and 16 had thymic carcinoma; patients had a median of two previous systemic regimens (range, one to 10 regimens). Treatment was well tolerated, with nausea, vomiting, and fatigue being the most frequent adverse effects. Two patients achieved partial response (both had thymoma; response rate, 8%; 95% CI, 2.2% to 25%), 25 had stable disease, and 13 had progressive disease; there were no responses among patients with thymic carcinoma. Median times to progression and survival were 5.8 and 19.1 months, respectively. Survival of patients with thymoma was significantly longer than that of patients with thymic carcinoma (median not reached v 12.4 months; P = .001). Protein acetylation, regulatory T-cell numbers, and circulating angiogenic factors did not predict outcome.

CONCLUSION:

Belinostat has modest antitumor activity in this group of heavily pretreated thymic malignancies. However, the duration of response and disease stabilization is intriguing, and additional testing of belinostat in this disease is warranted.

• Authors: Giuseppe Giaccone, Arun Rajan, Arlene Berman, Ronan J Kelly, Eva Szabo, Ariel Lopez-Chavez, Jane Trepel, Min-Jung Lee, Liang Cao, Igor Espinoza-Delgado, John Spittler, Patrick J Loehrer Sr
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 29 Issue 15 Pg. 2052-9 (May 20 2011) ISSN: 1527-7755 [Electronic] United States
• PMID: 21502553 (Publication Type: Clinical Trial, Phase II, Journal Article)

Chemical References

• Antineoplastic Agents
• Histone Deacetylase Inhibitors
• Hydroxamic Acids
• Sulfonamides
• belinostat

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (therapeutic use)
• Drug Resistance, Neoplasm
• Female
• Histone Deacetylase Inhibitors (therapeutic use)
• Humans
• Hydroxamic Acids (adverse effects, therapeutic use)
• Male
• Middle Aged
• Neoplasms, Glandular and Epithelial
• Recurrence
• Retreatment
• Sulfonamides
• Thymus Neoplasms
• Treatment Outcome