Abstract | BACKGROUND: METHODS: RESULTS: We included 2,721,014 women in the cohort, 27,087 of whom underwent surgical or laparoscopic cholecystectomy during the follow-up period. Compared with levonorgestrel, an older second-generation progestin, a small, statistically significant increase in the risk of gallbladder disease was associated with desogestrel (adjusted RR 1.05, 95% confidence interval [CI] 1.01-1.09), drospirenone (adjusted RR 1.20, 95% CI 1.16-1.26) and norethindrone (adjusted RR 1.10, 95% CI 1.06-1.14). No statistically significant increase in risk was associated with the other formulations of oral contraceptive ( ethynodiol diacetate, norgestrel and norgestimate). INTERPRETATION:
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Authors | Mahyar Etminan, Joseph A C Delaney, Brian Bressler, James M Brophy |
Journal | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
(CMAJ)
Vol. 183
Issue 8
Pg. 899-904
(May 17 2011)
ISSN: 1488-2329 [Electronic] Canada |
PMID | 21502354
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androstenes
- Contraceptives, Oral, Combined
- Contraceptives, Oral, Hormonal
- Contraceptives, Oral, Synthetic
- Progestins
- Ethinyl Estradiol
- Levonorgestrel
- Desogestrel
- drospirenone
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Topics |
- Adult
- Androstenes
(adverse effects)
- Cholecystectomy
(statistics & numerical data)
- Confidence Intervals
- Contraceptives, Oral, Combined
(adverse effects)
- Contraceptives, Oral, Hormonal
(adverse effects)
- Contraceptives, Oral, Synthetic
(adverse effects)
- Desogestrel
(adverse effects)
- Ethinyl Estradiol
(administration & dosage, adverse effects)
- Female
- Gallbladder Diseases
(chemically induced)
- Humans
- Levonorgestrel
(adverse effects)
- Progestins
(administration & dosage, adverse effects)
- Proportional Hazards Models
- Retrospective Studies
- Risk
- Risk Factors
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