A first report on Hb Q-Iran in association with alpha-thalassemia in a case of spinal ischemia.

Abstract

BACKGROUND:

Hemoglobin Q-Iran is a rare variant which has not been described in association with alpha-thalassemia to date. We present the case of a Turkish patient who developed spinal ischemia.

METHODS:

Spinal ischemia was diagnosed clinically, via magnetic resonance imaging and angiographically. Blood samples were analyzed by high performance liquid chromatography, electrophoresis, gene sequencing, hematological and biochemical analysis.

RESULTS:

We detected hemoglobin Q-Iran in association with alpha-thalassemia. The same hemoglobinopathy was detected in two members of the patient's family.

CONCLUSIONS:

As various differential diagnosis approaches failed to reveal the cause of spinal ischemia, the combined hemoglobinopathy was eventually postulated.

• Authors: Berndt Zur, Andreas Hildesheim, Michael Ludwig, Birgit Stoffel-Wagner
• Journal: Clinical laboratory (Clin Lab) Vol. 57 Issue 3-4 Pg. 221-4 ( 2011) ISSN: 1433-6510 [Print] Germany
• PMID: 21500730 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hemoglobins, Abnormal
• hemoglobin Q Iran

Topics

• Hemoglobins, Abnormal (analysis)
• Humans
• Male
• Middle Aged
• Spinal Cord Ischemia (blood, complications, diagnosis, genetics)
• Turkey
• alpha-Thalassemia (blood, complications, genetics)