[A case of hypopharyngeal cancer successfully treated with concurrent S-1, nedaplatin and radiotherapy].

Abstract

A 68-year-old man was admitted with hoarseness. Laryngofiberscopy showed a tumor that obstructed the posterior hypopharyngeal wall and the larynx, and biopsy revealed well-differentiated squamous cell carcinoma. CT demonstrated bilateral cervical lymph node metastases. The patient was diagnosed as having hypopharyngeal cancer(T4N2cM0)and was treated with concurrent S-1, nedaplatin and radiotherapy(hereafter referred to as SN therapy). CT and endoscopy after primary treatment showed disappearance of the tumor, and the treatment outcome was assessed as complete response(CR). Currently, the patient is being treated with S-1 as adjuvant chemotherapy in the outpatient setting, and no recurrence or metastasis has been observed. These results suggest that SN therapy was effective for advanced hypopharyngeal cancer from the viewpoint of both curative treatment and organ and function preservation.

• Authors: Rio Akiyama, Toshikazu Shimane, Sei Kobayashi, Kenichiro Ikeda, Shunya Egawa, Yoichi Ikenoya, Aya Uzuki, Akane Sugimoto, Takeshi Hayashi, Takeyuki Sanbe
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 4 Pg. 631-3 (Apr 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21498993 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Organoplatinum Compounds
• S 1 (combination)
• Tegafur
• Oxonic Acid
• nedaplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Drug Combinations
• Humans
• Hypopharyngeal Neoplasms (drug therapy, radiotherapy)
• Male
• Organoplatinum Compounds (administration & dosage, therapeutic use)
• Oxonic Acid (administration & dosage, therapeutic use)
• Tegafur (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed