Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma.

Abstract

BACKGROUND:

Several studies have suggested that fascin, cytokeratin 14 and cytokeratin 4 may have significant roles as biomarkers for the progression and survival of esophageal squamous cell carcinoma (ESCC).

MATERIALS AND METHODS:

This study performed immunohistochemistry in tissue microarrays, profiling premalignant lesions and invasive tumors.

RESULTS:

Fascin increased across the following states as follows: normal-appearing epithelium (26%) to dysplasia (46%) to ESCC (68%), while CK4 was undetectable in ESCC (0%) compared to normal-appearing epithelium (45%) or dysplasia (41%). CK14 was elevated and invariant in expression. In regression analyses, compared to normal-appearing epithelium, higher fascin expression was associated with a 36% increased risk of dysplasia (odds ratio=1.36) and a 56% increased risk of invasive ESCC (odds ratio=1.56).

CONCLUSION:

Expression of fascin is up-regulated in the transformation from normal-appearing epithelium, through dysplasia, into invasive carcinoma. Expression of CK4, CK14 and fascin did not correlate with patient survival. Fascin has a potential role as an early detection biomarker and CK4 as a tumor marker in ESCC.

• Authors: Mikiko Takikita, Nan Hu, Jian-Zhong Shou, Carol Giffen, Quan-Hong Wang, Chaoyu Wang, Stephen M Hewitt, Philip R Taylor
• Journal: Anticancer research (Anticancer Res) Vol. 31 Issue 3 Pg. 945-52 (Mar 2011) ISSN: 1791-7530 [Electronic] Greece
• PMID: 21498718 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Carrier Proteins
• Keratin-4
• Microfilament Proteins
• fascin

Topics

• Biomarkers, Tumor (genetics, metabolism)
• Biopsy
• Carcinoma, Squamous Cell (genetics, metabolism, pathology)
• Carrier Proteins (genetics, metabolism)
• Esophageal Neoplasms (genetics, metabolism, pathology)
• Female
• Genes, Neoplasm (genetics)
• Humans
• Immunohistochemistry
• Keratin-4 (genetics, metabolism)
• Male
• Microfilament Proteins (genetics, metabolism)
• Middle Aged
• Odds Ratio
• Regression Analysis
• Risk Factors
• Statistics, Nonparametric
• Survival Analysis
• Tissue Array Analysis