Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients.

Abstract

AIM:

Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions.

METHODS:

60 male type 2 diabetes patients (HbA(1c) 7.5±0.1% [58±1 mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring.

RESULTS:

Type 2 diabetes patients experienced hyperglycemia (glucose concentrations >10 mmol/L) 38±4% of the day. Even diabetes patients with an HbA(1c) level below 7.0% (53 mmol/mol) experienced hyperglycemia for as much as 24±5% throughout the day. Hyperglycemia was negligible in the control group (3±1%).

CONCLUSION:

Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA(1c) level well below 7.0% (53 mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.

• Authors: Jan-Willem van Dijk, Ralph J F Manders, Fred Hartgens, Coen D Stehouwer, Stephan F E Praet, Luc J C van Loon
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 93 Issue 1 Pg. 31-7 (Jul 2011) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 21497935 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A

Topics

• Blood Glucose (drug effects)
• Diabetes Mellitus, Type 2 (drug therapy, metabolism, physiopathology)
• Glycated Hemoglobin (metabolism)
• Humans
• Hyperglycemia (diagnosis, metabolism)
• Male
• Middle Aged