A new triterpene saponin from Androsace integra.

Abstract

A new triterpene saponin, androsacin (1), along with two known compounds, ardisiacrispin A (2) and saxifragifolin A (3), were isolated from the whole plants of Androsace integra. The chemical structure of the new compound was elucidated as 3β-O-{β-D-glucopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-[O-β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-16α-hydroxy-13β,28-epoxy-olean-30-al on the basis of spectral evidence. Ardisiacrispin A (2) was cytotoxic toward HepG2 cancer cell with the GI(50) value of 1.56μM.

• Authors: Weiwei Dong, Xin Liu, Xiaobo Li, Dajian Yang, Lisheng Ding
• Journal: Fitoterapia (Fitoterapia) Vol. 82 Issue 5 Pg. 782-5 (Jul 2011) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 21497642 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Plant Extracts
• Saponins
• Triterpenes
• androsacin
• ardisiacrispin A
• Oleanolic Acid

Topics

• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology, therapeutic use)
• Carcinoma, Hepatocellular (drug therapy)
• Hep G2 Cells
• Humans
• Liver Neoplasms (drug therapy)
• Molecular Structure
• Oleanolic Acid (analogs & derivatives, isolation & purification, pharmacology, therapeutic use)
• Phytotherapy
• Plant Extracts (chemistry, pharmacology, therapeutic use)
• Primulaceae (chemistry)
• Saponins (isolation & purification, pharmacology, therapeutic use)
• Triterpenes (isolation & purification, pharmacology, therapeutic use)