Spatial distribution of neo-intimal hyperplasia 6 months after zotarolimus-eluting stent implantation, analysed by optical coherence tomography.

Abstract

BACKGROUND:

Optical coherence tomography is a high-resolution imaging technology that allows in vivo assessment of neointimal hyperplasia and strut coverage after coronary stenting.

AIM:

Assessment of spatial distribution of healing, 6 months after zotarolimus-eluting stent implantation.

METHODS:

Forty-two zotarolimus-eluting stents were monitored by optical coherence tomography 6 months after implantation. Mean neointimal strut coverage thickness and percentage of neointimal hyperplasia were measured every millimetre. Non-covered strut ratios were assessed on each slice. In addition, the spatial distribution of neointimal hyperplasia and strut coverage were analysed longitudinally on five stent segments and axially on each slice.

RESULTS:

There were no clinical events at 6 months under dual antiplatelet therapy. The optical coherence tomography analysis showed a mean neointimal hyperplasia thickness of 333±147μm and neointimal hyperplasia obstruction of 36.1±12.3%. The percentage of covered struts at 6 months was very high (98.9%). Only 6/745 slices analysed (0.8%) had non-covered strut ratios exceeding 30%. There was no significant heterogeneity in either longitudinal or axial neointimal hyperplasia distribution. No thrombi were observed.

CONCLUSION:

This optical coherence tomography study found relatively constant neointimal hyperplasia thickness, regardless of the zotarolimus-eluting stent length or diameter. This spatially homogeneous neointimal hyperplasia was associated with near-total coverage of all struts, 6 months after implantation.

• Authors: Geraud Souteyrand, Sebastien Levesque, Lemlih Ouchchane, Laurent Sarry, Romain Eschalier, Jean-René Lusson, Pascal Motreff
• Journal: Archives of cardiovascular diseases (Arch Cardiovasc Dis) Vol. 104 Issue 3 Pg. 147-54 (Mar 2011) ISSN: 1875-2128 [Electronic] Netherlands
• PMID: 21497303 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Chemical References

• Cardiovascular Agents
• Platelet Aggregation Inhibitors
• zotarolimus
• Sirolimus

Topics

• Aged
• Angioplasty, Balloon, Coronary (adverse effects, instrumentation)
• Cardiovascular Agents (administration & dosage)
• Coronary Angiography
• Coronary Restenosis (etiology, pathology, prevention & control)
• Coronary Vessels (pathology)
• Drug Therapy, Combination
• Drug-Eluting Stents
• Female
• France
• Humans
• Hyperplasia
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (therapeutic use)
• Prospective Studies
• Prosthesis Design
• Sirolimus (administration & dosage, analogs & derivatives)
• Time Factors
• Tomography, Optical Coherence
• Treatment Outcome
• Tunica Intima (pathology)