In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes.

Abstract

Conventional reactions of the versatile multidentate ligand 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one (HmtpO) with metallic(II) perchlorate salts lead to three novel multidimensional complexes [Cu(HmtpO)(2)(H(2)O)(3)](ClO(4))(2)·H(2)O (1), {[Cu(HmtpO)(2)(H(2)O)(2)](ClO(4))(2) ·2HmtpO}(n) (2) and {[Co(HmtpO)(H(2)O)(3)](ClO(4))(2)·2H(2)O}(n) (3). We have tested the antiparasital activity in vitro and in vivo of the three new complexes against Trypanosoma cruzi showing very promising results and overcoming clearly the reference drug commonly used for the Chagas disease treatment, benznidazole.

• Authors: Ana B Caballero, Clotilde Marín, Antonio Rodríguez-Diéguez, Inmaculada Ramírez-Macías, Elisa Barea, Manuel Sánchez-Moreno, Juan M Salas
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 105 Issue 6 Pg. 770-6 (Jun 2011) ISSN: 1873-3344 [Electronic] United States
• PMID: 21497152 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Coordination Complexes
• Ligands
• Nitroimidazoles
• Perchlorates
• Pyrimidinones
• Triazoles
• Trypanocidal Agents
• perchlorate
• benzonidazole

Topics

• Animals
• Chagas Disease (drug therapy)
• Chlorocebus aethiops
• Coordination Complexes (chemistry, pharmacology)
• Crystallography, X-Ray
• Female
• Ligands
• Mice
• Mice, Inbred BALB C
• Microscopy, Electron, Transmission
• Nitroimidazoles (chemistry)
• Perchlorates (chemistry)
• Pyrimidinones (chemistry, pharmacology)
• Triazoles (chemistry, pharmacology)
• Trypanocidal Agents (chemistry, pharmacology)
• Trypanosoma cruzi (drug effects)
• Vero Cells