Abstract | REASONS FOR PERFORMING STUDY: Studies investigating the clinical efficacy of albuterol administered with the same propellant and commercially available delivery devices in horses with recurrent airway obstruction (RAO) are not currently available. OBJECTIVES: To determine the efficacy of aerosolised albuterol administered to horses with RAO by means of 2 commercially available, hand-held delivery devices. METHODS: Ten horses with RAO were kept in a dusty environment and fed mouldy hay to induce airway obstruction. Lung mechanics were measured before and after the procedure. ΔP(max) was measured 5 min after administration of 180 µg of albuterol from a pressurised metered dose inhaler, using an aerosol delivery device chosen randomly. This process was repeated every 5 min until maximal bronchodilation was achieved. After a 24 h washout period, lung mechanics data were again collected using the other aerosol delivery device. RESULTS: Aerosolised albuterol induced a significant and rapid bronchodilation in the horses using both aerosol delivery devices. No statistically significant difference in pulmonary function was observed in response to albuterol therapy between the 2 devices. The dose required to achieve 50% of maximal bronchodilation was not statistically different between the 2 devices (173.35 ± 78.35 µg with Device 1 and 228.49 ± 144.99 µg with Device 2, P = 0.26). The decrease in lung resistance tended to be more pronounced after albuterol administration with Device 1 (P = 0.066). CONCLUSIONS: POTENTIAL RELEVANCE: Aerosolised albuterol is effectively delivered using currently available devices leading to maximal bronchodilation in horses with RAO at an average dose of 540 µg.
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Authors | F R Bertin, K M Ivester, L L Couëtil |
Journal | Equine veterinary journal
(Equine Vet J)
Vol. 43
Issue 4
Pg. 393-8
(Jul 2011)
ISSN: 2042-3306 [Electronic] United States |
PMID | 21496081
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 EVJ Ltd. |
Chemical References |
- Bronchodilator Agents
- Albuterol
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Topics |
- Administration, Inhalation
- Airway Obstruction
(drug therapy, veterinary)
- Albuterol
(administration & dosage)
- Animals
- Bronchodilator Agents
(administration & dosage)
- Female
- Horse Diseases
(drug therapy)
- Horses
- Male
- Metered Dose Inhalers
(standards, veterinary)
- Respiratory Function Tests
(veterinary)
- Statistics, Nonparametric
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