HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study.

AbstractBACKGROUND:
Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris.
OBJECTIVES:
To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0·1%-BPO 2·5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris.
METHODS:
A total of 378 subjects were randomized in a double-blind, controlled trial to receive once-daily lymecycline with either A/BPO or vehicle for 12 weeks. Evaluations included percentage changes from baseline in lesion counts, success rate (subjects 'clear' or 'almost clear'), skin tolerability, adverse events and patients' satisfaction.
RESULTS:
The median percentage reduction from baseline in total lesion counts at week 12 was significantly higher (P < 0·001) in the lymecycline with A/BPO group (-74·1%) than in the lymecycline with vehicle group (-56·8%). The success rate was significantly higher (47·6% vs. 33·7%, P = 0·002) in subjects treated with lymecycline and A/BPO. Both inflammatory and noninflammatory lesions were significantly reduced at week 12 (both P < 0·001) with a rapid onset of action from week 2 for noninflammatory lesions (P < 0·001) and week 4 for inflammatory lesions (P = 0·005). The A/BPO and lymecycline combination was well tolerated. The proportion of satisfied and very satisfied subjects was similar in both groups, but the number in the A/BPO group who were 'very satisfied' was significantly greater (P = 0·031).
CONCLUSION:
These results demonstrate the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris.
AuthorsB Dréno, R Kaufmann, S Talarico, V Torres Lozada, M A Rodríguez-Castellanos, M Gómez-Flores, J De Maubeuge, M Berg, P Foley, A Sysa-Jedrzejowska, N Kerrouche, F Paliargues, V Bettoli
JournalThe British journal of dermatology (Br J Dermatol) Vol. 165 Issue 2 Pg. 383-90 (Aug 2011) ISSN: 1365-2133 [Electronic] England
PMID21495995 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Copyright© 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011.
Chemical References
  • Anti-Bacterial Agents
  • Dermatologic Agents
  • Gels
  • Naphthalenes
  • Pharmaceutical Vehicles
  • Adapalene
  • Lymecycline
  • Benzoyl Peroxide
Topics
  • Acne Vulgaris (drug therapy)
  • Adapalene
  • Administration, Oral
  • Administration, Topical
  • Adolescent
  • Adult
  • Anti-Bacterial Agents (administration & dosage, adverse effects)
  • Benzoyl Peroxide (administration & dosage, adverse effects)
  • Child
  • Dermatologic Agents (administration & dosage, adverse effects)
  • Double-Blind Method
  • Drug Therapy, Combination (methods)
  • Female
  • Gels
  • Humans
  • Lymecycline (administration & dosage, adverse effects)
  • Male
  • Naphthalenes (administration & dosage, adverse effects)
  • Patient Satisfaction
  • Pharmaceutical Vehicles
  • Treatment Outcome
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: