[Efficacy and tolerability of paracetamol-sobrerol combination in patients with hyperpyrexia].
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| Abstract |
The therapeutic efficacy and tolerability of the association paracetamol-sobrerol in comparison with paracetamol alone, was tested in a double-blind, randomized clinical trial, carried out on 287 out-patients, suffering from diseases of the respiratory tree with fever. The treatment was performed for up to five days. At the end of the treatment, both treatments lead to an important improvement of all considered clinical parameters; furthermore, the association paracetamol-sobrerol showed a statistically important difference versus paracetamol alone as to cough and difficulty to expectorate. As to body temperature, both paracetamol and paracetamol-sobrerol showed a good antipyretic activity; furthermore, the association compared to paracetamol alone obtained a statistically significant differences in times x treatments. These data fully confirm the results obtained from recent studies: the simultaneous administration of paracetamol and sobrerol obtains a better antipyretic action than paracetamol alone. This synergism allows to reduce paracetamol doses and, consequently, to eliminate the already low incidence of adverse reactions, without decreasing the antipyretic activity.
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| Authors | C F Marchioni, C Gramolini, P Guerzoni, M Corona, M Corradini |
| Journal | La Clinica terapeutica (Clin Ter) Vol. 135 Issue 2 Pg. 105-13 (Oct 31 1990) ISSN: 0009-9074 [Print] Italy |
| Vernacular Title | Efficacia e tollerabilità dell'associazione paracetamolo-sobrerolo nel paziente iperpiretico. |
| PMID | 2149543 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial) |
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