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T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement.

Abstract
We reported recently that intracerebral administration of NMO-IgG with human complement produces neuromyelitis optica (NMO) lesions in mice. We examined the role of T cells in the formation of NMO lesions by comparing brain histopathology in wildtype and nude mice. Brains were co-injected with IgG from NMO patients and human complement. At 24h and 5days, wildtype vs. nude mouse brains had comparable inflammation (CD45 immunoreactivity), loss of myelin (Luxol Fast Blue staining) and loss of AQP4 immunoreactivity. We conclude that T cells are not required for the formation of NMO lesions in this mouse model.
AuthorsSamira Saadoun, Patrick Waters, Claire Macdonald, Leslie R Bridges, B Anthony Bell, Angela Vincent, A S Verkman, Marios C Papadopoulos
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 235 Issue 1-2 Pg. 27-32 (Jun 2011) ISSN: 1872-8421 [Electronic] Netherlands
PMID21492943 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier B.V. All rights reserved.
Chemical References
  • Immunoglobulin G
  • Complement System Proteins
Topics
  • Animals
  • Brain (immunology, pathology)
  • Complement System Proteins (administration & dosage)
  • Humans
  • Immunoglobulin G (administration & dosage)
  • Immunologic Deficiency Syndromes (immunology, pathology)
  • Injections, Intraventricular
  • Mice
  • Mice, Knockout
  • Mice, Nude
  • Neuromyelitis Optica (immunology, pathology)
  • T-Lymphocytes (immunology, pathology)

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