Efficacy of experimental Newcastle disease water-in-oil oil-emulsion vaccines formulated from squalane and squalene.

Abstract

Water-in-oil inactivated Newcastle disease oil-emulsion vaccines were formulated with the terpene oils squalane or squalene, or mixtures thereof, and injected into 4-week-old broilers. Vaccine efficacy based on hemagglutination-inhibition (HI) titers was comparable to that of control mineral oil vaccines. Tissue reaction to intramuscular injection of the terpene oil emulsion vaccines was greatly reduced 3 weeks post-vaccination compared with that of mineral oil-based vaccine. Viscosity of the terpene oil vaccines was satisfactory but increased three to four times that of mineral oil vaccine when the antigen phase volume increased from 5% to 20%.

• Authors: H D Stone, Z X Xie
• Journal: Avian diseases (Avian Dis) 1990 Oct-Dec Vol. 34 Issue 4 Pg. 979-83 ISSN: 0005-2086 [Print] United States
• PMID: 2149264 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Viral Vaccines
• Squalene
• squalane

Topics

• Animals
• Antibodies, Viral (biosynthesis)
• Chickens (immunology)
• Hemagglutination Inhibition Tests
• Muscles (pathology)
• Newcastle disease virus (immunology)
• Specific Pathogen-Free Organisms
• Squalene (analogs & derivatives)
• Viral Vaccines (adverse effects, immunology)
• Viscosity