Abstract | BACKGROUND: METHODS: Eighty-six patients admitted within 6 hrs after ICH and 30 healthy controls were included. Plasma samples were obtained on admission and at days 1, 2, 3, 5, and 7 after ICH. Its concentration was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: After ICH, plasma leptin level in patients increased during the 6-hour period immediately, peaked in 24 hours, decreased gradually thereafter, and was substantially higher than that in healthy controls during the 7-day period. Plasma leptin levels were highly associated with initial Glasgow coma scores, ICH volumes, presence of intraventricular hemorrhage, and survival rates (all P < 0.05). A multivariate analysis selected plasma leptin level related to plasma C-reactive protein level (standardized coefficient, 0.293; P = 0.003). A multivariate analysis showed baseline plasma leptin level as a good predictor for 1-week mortality (odds ratio, 1.228; 95% confidence interval, 1.070-1.409; P = 0.003). A receiver operating characteristic curve identified that a baseline plasma leptin level greater than 34.1 ng/mL predicted 1-week mortality of patients with 75.0% sensitivity and 85.2% specificity (P < 0.001). Area under curve of GCS score was statistically significantly larger than that of plasma leptin level (P = 0.035), but ICH volume's area under curve not (P = 0.078). CONCLUSIONS: Increased plasma leptin level is found after ICH and may contribute to inflammatory process of ICH, in association with a poor clinical outcome.
|
Authors | Xiao-Qiao Dong, Man Huang, Yue-Yu Hu, Wen-Hua Yu, Zu-Yong Zhang |
Journal | World neurosurgery
(World Neurosurg)
2010 Aug-Sep
Vol. 74
Issue 2-3
Pg. 286-93
ISSN: 1878-8769 [Electronic] United States |
PMID | 21492562
(Publication Type: Journal Article)
|
Copyright | Copyright © 2010 Elsevier Inc. All rights reserved. |
Chemical References |
|
Topics |
- Aged
- Basal Ganglia Hemorrhage
(blood, mortality, therapy)
- Biomarkers
- Blood Chemical Analysis
- Combined Modality Therapy
- Endpoint Determination
- Enzyme-Linked Immunosorbent Assay
- Female
- Glasgow Coma Scale
- Hemodynamics
- Humans
- Leptin
(blood)
- Male
- Middle Aged
- Neurosurgical Procedures
- Survival
- Tomography, X-Ray Computed
- Treatment Outcome
|