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T-cell response to superantigen restimulation during menstrual toxic shock syndrome.

Abstract
Menstrual toxic shock syndrome (MTSS) is a severe toxin-mediated disease associated with Staphylococcus aureus producing toxic shock syndrome toxin 1 (TSST-1), a superantigen that mediates a potent activation of Vβ-2 T cells. In animal models, superantigen treatment of responsive T cells induces their initial proliferation, followed by unresponsiveness upon further superantigen stimulation. To determine whether T cell unresponsiveness occurs in humans during the acute phase of MTSS, we collected T cells from a patient with MTSS and restimulated them ex vivo with recombinant TSST-1. The expansion of T cells collected during the acute phase of disease was compared with positive controls including basal-state T cells (collected 70 days after MTSS) restimulated with TSST-1, and T cells stimulated with enterotoxin B superantigen. We found that TSST-1-induced expansion of acute phase T cells was not inferior to that observed in positive controls. We conclude that T cells were still reactive to TSST-1 during the acute phase of MTSS in this patient. As the persistence of TSST-1 production could thus be associated with further expansion of TSST-1-reactive T cells and a rapid worsening of symptoms, this study adds further support to the need for immediate eradication of the focus of infection as soon as MTSS is suspected.
AuthorsJean-Philippe Rasigade, Damien Thomas, Thomas Perpoint, Dominique Peyramond, Christian Chidiac, Jerome Etienne, François Vandenesch, Gerard Lina, Tristan Ferry
JournalFEMS immunology and medical microbiology (FEMS Immunol Med Microbiol) Vol. 62 Issue 3 Pg. 368-71 (Aug 2011) ISSN: 1574-695X [Electronic] England
PMID21492259 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Chemical References
  • Bacterial Toxins
  • Enterotoxins
  • Superantigens
  • enterotoxin F, Staphylococcal
  • enterotoxin B, staphylococcal
Topics
  • Adolescent
  • Bacterial Toxins (immunology)
  • Cells, Cultured
  • Enterotoxins (immunology)
  • Female
  • Flow Cytometry
  • Humans
  • Leukocytes, Mononuclear (immunology)
  • Lymphocyte Activation
  • Menstruation
  • Shock, Septic (immunology)
  • Staphylococcal Infections (immunology)
  • Staphylococcus aureus (immunology, metabolism)
  • Superantigens (immunology)
  • T-Lymphocytes (cytology, immunology)

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