Abstract |
The objective of this study was to investigate the pharmacokinetics and bioavailability of valnemulin in broiler chickens after intravenous (i.v.), intramuscular (i.m.) and oral administrations of 10 mg/kg body weight (bw). Plasma samples were analyzed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Pharmacokinetic characterization was performed by non-compartmental analysis using WinNonlin program. After intravenous administration, distribution was wide with the volume of distribution based on terminal phase(V(z)) of 4.27 ± 0.99 L /kg. Mean valnemulin t(1/2β)(h), Cl(β)(L /h /kg), V(ss)(L /kg) and AUC((0-∞))(μg·h /mL) values were 2.85, 0.99, 2.72 and 10.34, respectively. After intramuscular administration, valnemulin was rapidly absorbed with a C(max) of 2.2 μg/mL achieved at 0.43 h (t(max)), and the absolute bioavailability (F) was 88.81%; and for the oral route the same parameters were 0.66 ± 0.15 μg/mL, 1.54 ± 0.27 h and 74.42%. A multiple-peak phenomenon was present after oral administration. The plasma profile of valnemulin exhibited a secondary peak during 2-6 h and a tertiary peak at 32 h. The favorable PK behavior, such as the wide distribution, slow elimination and acceptable bioavailability indicated that it is likely to be effective in chickens.
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Authors | R Wang, L G Yuan, L M He, L X Zhu, X Y Luo, C Y Zhang, J J Yu, B H Fang, Y H Liu |
Journal | Journal of veterinary pharmacology and therapeutics
(J Vet Pharmacol Ther)
Vol. 34
Issue 3
Pg. 247-51
(Jun 2011)
ISSN: 1365-2885 [Electronic] England |
PMID | 21492189
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 Blackwell Publishing Ltd. |
Chemical References |
- Anti-Bacterial Agents
- Diterpenes
- valnemulin
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Topics |
- Administration, Oral
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacokinetics)
- Biological Availability
- Chickens
(metabolism)
- Chromatography, High Pressure Liquid
(veterinary)
- Diterpenes
(administration & dosage, pharmacokinetics)
- Drug Administration Schedule
(veterinary)
- Injections, Intramuscular
(veterinary)
- Injections, Intravenous
(veterinary)
- Random Allocation
- Tandem Mass Spectrometry
(veterinary)
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