Abstract | OBJECTIVES: Rhus verniciflua Stokes (RVS), which has valuable medicinal properties, has for many years been prescribed for inflammation in east Asian medicine. Recent studies suggest that RVS has potent antioxidative, antitumor and anti-inflammatory properties. METHODS: In this study, the anti-inflammatory effects of RVS in vitro and in vivo were investigated. The ethanol extract from RVS was partitioned with different solvents in order of increasing polarity. KEY FINDINGS: CONCLUSIONS: These results suggest that RVS could be a promising candidate agent for inflammation prevention and combination therapy with anti-inflammatory drugs.
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Authors | Chang Hwa Jung, Jeong-Hyun Kim, Ji Hye Kim, Joo Hee Chung, Han-Seok Choi, Jong Bok Seo, Yong-Cheol Shin, Sung-Hoon Kim, Seong-Gyu Ko |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 63
Issue 5
Pg. 679-87
(May 2011)
ISSN: 2042-7158 [Electronic] England |
PMID | 21492170
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society. |
Chemical References |
- Anti-Inflammatory Agents
- Lipopolysaccharides
- Plant Extracts
- Reactive Oxygen Species
- Nitric Oxide
- Carrageenan
- Nitric Oxide Synthase Type II
- Proto-Oncogene Proteins c-akt
- Extracellular Signal-Regulated MAP Kinases
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Carrageenan
- Cells, Cultured
- Disease Models, Animal
- Edema
(drug therapy)
- Extracellular Signal-Regulated MAP Kinases
(antagonists & inhibitors)
- Lipopolysaccharides
- Macrophages
(drug effects, metabolism)
- Mice
- Nitric Oxide
(antagonists & inhibitors)
- Nitric Oxide Synthase Type II
(antagonists & inhibitors)
- Phosphorylation
- Phytotherapy
- Plant Bark
- Plant Extracts
(pharmacology)
- Proto-Oncogene Proteins c-akt
(antagonists & inhibitors)
- Reactive Oxygen Species
(antagonists & inhibitors)
- Rhus
- Signal Transduction
(drug effects)
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