Abstract | BACKGROUND: OBJECTIVE: METHODS: In this double-blind, randomized, crossover study 18 subjects with allergic rhinitis to grass pollen received Ze 339, desloratadine, and placebo for 5 days before nasal allergen challenge with grass pollen extract. Rhinomanometry, symptom assessment, and local inflammatory mediator measurement were performed during the 24 hours after allergen challenge. RESULTS: With Ze 339, the patient's time to recovery (5.4 ± 1.6 hours) from nasal obstruction after allergen challenge (time for return to 90% of baseline value ± SEM) was significantly shorter than with placebo (9.1 ± 2.3 hours, P = .035) and desloratadine (10.7 ± 2.5 hours, P = .022). Likewise, Ze 339's standardized symptom assessment for nasal obstruction (3.2 ± 1.3 hours) showed significantly faster relief (time for return to baseline value ± SEM compared with placebo, 8.3 ± 2.4 hours; P = .027) and desloratadine (4.5 ± 1.2 hours, P = .030). One interesting finding was that Ze 339 significantly reduced IL-8 and leukotriene B(4) levels in nasal secretions before challenge. CONCLUSION:
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Authors | Alina F Dumitru, Mohamed Shamji, Martin Wagenmann, Simone Hindersin, Kathrin Scheckenbach, Jens Greve, Thomas Klenzner, Lorenzo Hess, Sabine Nebel, Christian Zimmermann, Catherine Zahner, Carsten B Schmidt-Weber, Adam M Chaker |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 127
Issue 6
Pg. 1515-21.e6
(Jun 2011)
ISSN: 1097-6825 [Electronic] United States |
PMID | 21489609
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Allergens
- Anti-Allergic Agents
- CXCL8 protein, human
- Chemokines
- Cytokines
- Interleukin-8
- Plant Extracts
- Ze 339
- Leukotriene B4
- Loratadine
- desloratadine
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Topics |
- Adult
- Allergens
- Anti-Allergic Agents
(therapeutic use)
- Bronchial Provocation Tests
- Chemokines
(metabolism)
- Cross-Over Studies
- Cytokines
(metabolism)
- Double-Blind Method
- Female
- Humans
- Interleukin-8
(antagonists & inhibitors)
- Leukotriene B4
(antagonists & inhibitors)
- Loratadine
(analogs & derivatives, therapeutic use)
- Male
- Middle Aged
- Nasal Obstruction
(drug therapy, etiology, physiopathology)
- Plant Extracts
(therapeutic use)
- Pollen
- Rhinitis, Allergic, Seasonal
(complications, drug therapy, physiopathology)
- Young Adult
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