Abstract | BACKGROUND: Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non- otitis-prone), recurrent AOM ( otitis-prone), and AOM treatment failure (AOMTF) in children. OBJECTIVE: From a population of 268 children, we sought to compare the serum IgG antibody titers of 5 different Spn proteins (PhtD, LytB, PcpA, PhtE, and Ply) that are vaccine candidates in children with episodic AOM (n = 34), who were otitis prone (n = 35) and who had AOMTF (n = 25) caused by Spn. METHODS: RESULTS: At their AOM visit, anti-PhtD, -LytB, -PhtE, and -Ply IgG antibody titers in otitis-prone children were significantly lower compared with non- otitis-prone children (P < 0.05) and children with AOMTF (P < 0.05). On comparing acute to convalescent geometric mean IgG antibody titers after AOM against the 5 proteins we found that otitis-prone, AOMTF, and non- otitis-prone children had no significant change in titers (except for PhtE in children with AOMTF), but detailed analysis showed that about one-third of the children in each cohort had a 2-fold rise in antibody to the studied antigens. Although non- otitis-prone children had significant increases (P < 0.001) between 6 and 24 months of age in anti-PhtD, PcpA, PhtE, and Ply IgG antibody titers as a consequence of nasopharyngeal colonization and AOM, otitis-prone children either failed to show rises or the rises were significantly less than the non- otitis-prone children. CONCLUSION:
Otitis-prone and AOMTF children mount less of an IgG serum antibody response as compared with non- otitis-prone children to Spn proteins after AOM and nasopharyngeal colonization.
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Authors | Ravinder Kaur, Janet R Casey, Michael E Pichichero |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 30
Issue 8
Pg. 645-50
(Aug 2011)
ISSN: 1532-0987 [Electronic] United States |
PMID | 21487325
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Antigens, Bacterial
- Bacterial Proteins
- Immunoglobulin G
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Topics |
- Antibodies, Bacterial
(blood)
- Antigens, Bacterial
(immunology)
- Bacterial Proteins
(immunology)
- Child, Preschool
- Disease Susceptibility
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Immunoglobulin G
(blood)
- Infant
- Otitis Media
(immunology, microbiology)
- Pneumococcal Infections
(immunology, microbiology)
- Prospective Studies
- Serum
(immunology)
- Streptococcus pneumoniae
(immunology)
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