Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates.

Abstract

Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human cancer cell lines with IC(50) <30 μM. Structure-activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity.

• Authors: Xiao-Juan Wang, Hai-Wei Xu, Lin-Lin Guo, Jia-Xin Zheng, Bo Xu, Xiao Guo, Chen-Xin Zheng, Hong-Min Liu
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 21 Issue 10 Pg. 3074-7 (May 15 2011) ISSN: 1464-3405 [Electronic] England
• PMID: 21486694 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Thiocarbamates
• butenolide
• 4-Butyrolactone

Topics

• 4-Butyrolactone (analogs & derivatives, chemistry)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Proliferation (drug effects)
• Drug Design
• Humans
• Inhibitory Concentration 50
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Structure-Activity Relationship
• Thiocarbamates (chemical synthesis, chemistry, pharmacology)