Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids from Indonesian, Tahitian and Japanese liverworts.

Abstract

Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids have been isolated from unidentified Indonesian and Tahitian Frullania sp. and Japanese Porella perrottetiana by using a combination of chromatographic methods. The structure activity relationship (SAR) study showed that the presence of a phthalide group in bibenzyls, an alpha-methylene-gamma-lactone in germacrane-type sesquiterpenoids, and beta-hydroxycarbonyl in pinguisane-type sesquiterpenoids play an important role in providing cytotoxic activity against both human promyelocytic leukemia (HL-60) and human pharyngeal squamous carcinoma (KB) cell lines. The structure of each isolated compound was elucidated by using spectroscopic methods and the cytotoxicity was determined by using the WST-8 colorimetric assay.

• Authors: Ismiarni Komala, Takuya Ito, Fumihiro Nagashima, Yasuyuki Yagi, Yoshinori Asakawa
• Journal: Natural product communications (Nat Prod Commun) Vol. 6 Issue 3 Pg. 303-9 (Mar 2011) ISSN: 1934-578X [Print] United States
• PMID: 21485264 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Benzyl Compounds
• Indicators and Reagents
• Plant Extracts
• Sesquiterpenes, Germacrane

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Benzyl Compounds (chemistry, pharmacology)
• Cell Line, Tumor
• HL-60 Cells
• Hepatophyta (chemistry)
• Humans
• Indicators and Reagents
• Indonesia
• Japan
• KB Cells
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Plant Extracts
• Polynesia
• Sesquiterpenes, Germacrane (chemistry, pharmacology)
• Structure-Activity Relationship