Epilepsia partialis continua associated with levamisole.

Abstract

Epilepsia partialis continua is defined as a spontaneous regular or irregular clonic muscular twitching affecting a limited part of the body, occurring for a minimum of 1 hour and recurring at intervals of less than 10 seconds. Levamisole is used as an immunomodulating medication in patients with recurrent aphthous ulcers. Evidence suggests that it can induce multifocal inflammatory leukoencephalopathy. We describe the clinical neuroimaging and ictal electroencephalographic findings in an adolescent with epilepsia partialis continua caused by the administration of levamisole with cortical and subcortical lesions. To our knowledge, this is the first report that describes the association of epilepsia partialis continua cortical lesions detected by magnetic resonance imaging and levamisole that were not previously described.

• Authors: Marina N Aberastury, Walter H Silva, Maria M Vaccarezza, Clarisa Maxit, Guillermo Agosta
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 44 Issue 5 Pg. 385-8 (May 2011) ISSN: 1873-5150 [Electronic] United States
• PMID: 21481750 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Adjuvants, Immunologic
• Levamisole

Topics

• Adjuvants, Immunologic (adverse effects)
• Adolescent
• Epilepsia Partialis Continua (chemically induced, diagnosis, drug therapy)
• Female
• Frontal Lobe (drug effects, pathology)
• Humans
• Levamisole (adverse effects)
• Magnetic Resonance Imaging
• Stomatitis, Aphthous (drug therapy)