Abstract | BACKGROUND: METHODS: The relationships of plasma PLTP activity levels ( phospholipid vesicles-HDL system) with waist circumference, waist/hip ratio, body mass index (BMI) and insulin resistance (homeostasis model assessment (HOMA(ir))) were determined in 313 non-diabetic subjects (273 men). RESULTS: PLTP activity was higher in 67 subjects with enlarged waist circumference (NCEP- ATP-III criteria; 102 ± 11 AU) compared to 246 subjects with normal waist (98 ± 11 AU, P=0.027). In univariate analysis PLTP activity correlated positively with waist (r=0.188), waist/hip ratio (r=0.143), BMI (r=0.125) and HOMA(ir) (r=0.192) (P<0.05 to P<0.001). The relationship of PLTP with HOMA(ir) was confined to subjects with the highest waist circumference and waist/hip ratio. In age- and sex-adjusted multiple linear regression models, waist circumference (β=0.158, P=0.025), but not BMI, predicted PLTP activity independently of HOMA(ir) (β=0.126, P=0.047). Furthermore, both waist and waist/hip ratio interacted positively with HOMA(ir) on PLTP activity (β=0.109, P=0.056 and β=0.156, P=0.034, respectively). CONCLUSIONS:
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Authors | Rindert de Vries, Paul J W H Kappelle, Geesje M Dallinga-Thie, Robin P F Dullaart |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 217
Issue 1
Pg. 253-9
(Jul 2011)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 21481395
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Lipoproteins, HDL
- Phospholipid Transfer Proteins
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Topics |
- Adiposity
- Adult
- Aged
- Body Mass Index
- Female
- Gene Expression Regulation
- Humans
- Insulin Resistance
- Lipoproteins, HDL
(metabolism)
- Male
- Middle Aged
- Obesity
(blood)
- Phospholipid Transfer Proteins
(blood)
- Risk Factors
- Waist Circumference
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