Abstract | AIM: To evaluate the benefits of initiating insulin at an earlier versus later treatment stage, and regimens with/without sulfonylurea (SU). METHODS: Pooled analysis of 11 prospective randomized clinical trials, including 2171 adults with uncontrolled type 2 diabetes initiating insulin glargine following a specific titration algorithm. Clinical outcomes were glycated haemoglobin A1c (HbA1c) reduction, per cent achieving HbA1c ≤ 7.0%, weight gain and hypoglycaemic events. Statistical analysis compared outcomes 24 weeks after basal insulin initiation in patients previously uncontrolled on 0/1 oral antidiabetic drug (OAD) versus 2 OADs, and in patients taking metformin (MET) or SU alone or in combination at baseline. A meta-analysis was also conducted. RESULTS: For the pooled analysis, patients on 0/1 OAD and those on MET monotherapy at baseline had the largest 24-week reductions in HbA1c following the addition of insulin glargine (∼0.44 U/kg). Of patients failing MET/SU monotherapy and MET + SU in combination, 68.1, 50.4 and 56.4% achieved HbA1c ≤ 7.0%, respectively (p = 0.0006). Weight gain was lowest when basal insulin was added to MET. Patients on 0/1 OAD at baseline had significantly less symptomatic hypoglycaemia when basal insulin was added than those on 2 OADs (p = 0.0007). Despite higher insulin doses, those taking MET alone had less hypoglycaemia than those taking SU or MET + SU. Results were confirmed in the meta-analysis. CONCLUSION: Adding insulin glargine to MET monotherapy early in treatment may provide efficacy/safety benefits over regimens including SU. This may reflect treatment earlier in the disease and supports the inclusion of insulin as a second step in the American Diabetes Association/European Association for the Study of Diabetes treatment algorithm.
|
Authors | V Fonseca, J Gill, R Zhou, J Leahy |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 13
Issue 9
Pg. 814-22
(Sep 2011)
ISSN: 1463-1326 [Electronic] England |
PMID | 21481127
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
|
Copyright | © 2011 Blackwell Publishing Ltd. |
Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
- Insulin, Long-Acting
- Sulfonylurea Compounds
- Insulin Glargine
- Metformin
|
Topics |
- Algorithms
- Blood Glucose
(drug effects, physiology)
- Diabetes Mellitus, Type 2
(drug therapy, physiopathology)
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Glycated Hemoglobin
(drug effects, physiology)
- Humans
- Hypoglycemia
(drug therapy, physiopathology)
- Hypoglycemic Agents
(administration & dosage, pharmacology)
- Insulin
(administration & dosage, analogs & derivatives, pharmacology)
- Insulin Glargine
- Insulin, Long-Acting
- Male
- Metformin
(administration & dosage, pharmacology)
- Middle Aged
- Prospective Studies
- Randomized Controlled Trials as Topic
- Sulfonylurea Compounds
(administration & dosage, pharmacology)
- Treatment Outcome
|