Abstract | INTRODUCTION: Primary parotid malignancies represent a rare diagnosis, making high-quality comparative research unfeasible. There is little U.K.-based evidence to guide practice. A review was therefore undertaken of a large series of patients treated by a multidisciplinary team in a National Health Service tertiary referral centre. PATIENTS AND METHODS: Retrospective patient record review at the John Radcliffe Hospital in Oxford identified 401 patients who had undergone parotidectomy between 1995 and 2010, of whom 50 subjects were given a definitive diagnosis of primary parotid malignancy, treated with surgery and postoperative radiotherapy. Case notes, histology and imaging were reviewed by the study team. RESULTS: The median follow up for the cohort was 60 months (range: 1-108 months). Facial nerve function was preserved in all patients undergoing partial or total conservative parotidectomy. Although histology showed microscopically close or positive margins in 82% of cases, all patients underwent postoperative radiotherapy and locoregional recurrence was identified in only two (4%) patients. CONCLUSIONS: The data presented demonstrate a reasonable and practical multidisciplinary approach to a complex management problem. Facial nerve sparing surgery and postoperative radiotherapy result in good control of locoregional disease.
|
Authors | Ketan Shah, Faisal Javed, Chris Alcock, Ketan A Shah, Pieter Pretorius, Chris A Milford |
Journal | Annals of the Royal College of Surgeons of England
(Ann R Coll Surg Engl)
Vol. 93
Issue 3
Pg. 218-22
(Apr 2011)
ISSN: 1478-7083 [Electronic] England |
PMID | 21477434
(Publication Type: Journal Article)
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biopsy, Fine-Needle
- Combined Modality Therapy
(methods)
- Epidemiologic Methods
- Facial Paralysis
(prevention & control)
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(pathology)
- Neoplasm Staging
- Parotid Neoplasms
(pathology, radiotherapy, surgery)
- Positron-Emission Tomography
- Tomography, X-Ray Computed
- Treatment Outcome
- Young Adult
|