Abstract | BACKGROUND: METHODS: The DNA of 35 female breast cancer patients and 33 healthy individuals, in the Kashmiri population from India, were analyzed using a PCR-RFLP approach for the above mentioned polymorphisms. RESULTS: Individuals carrying the MTHFR 677CT/TT and GCPII 1561 CT genotype showed a 3.5 (95% CI: 3.1-3.7, P<0.02) and 7.7 (95% CI: 6.7-9.1, P<0.001) fold decreased risk for breast cancer than the wild types (MTHFR 677CC and GCPII 1561 CC). Subjects with MTRR 66 G-allele showed a 4.5 fold decreased risk (OR: 0.22, 95% CI: 0.20, 0.24, P<0.0005) compared to the wild type (MTRR 66A). Further, subjects with combined polymorphisms in MTHFR, GCPII and MTRR loci revealed a significant reduction of breast cancer risk. CONCLUSION: This study indicates (i) a protective role of polymorphisms in MTHFR, GCPII, MTRR against breast cancer in the study subjects, and (ii) combined effect of polymorphisms is more pronounced than single genetic polymorphism, thereby emphasizing the role of gene-gene interaction in the susceptibility to breast cancer.
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Authors | M Muzaffar Mir, Javid A Dar, Nazir A Dar, M Shafi Dar, Irfana Salam, M Maqbool Lone, Nissar A Chowdary |
Journal | International journal of health sciences
(Int J Health Sci (Qassim))
Vol. 2
Issue 1
Pg. 3-14
(Jan 2008)
ISSN: 1658-3639 [Print] Saudi Arabia |
PMID | 21475466
(Publication Type: Journal Article)
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