Successful treatment of childhood prolonged refractory status epilepticus with lacosamide.

Abstract

Prolonged, refractory status epilepticus is a rare clinical syndrome that is associated with severe morbidity and mortality. Lacosamide is a newly approved medication for treatment of partial onset seizures in adults, which has a novel mechanism of action. Experimental data and recent reports suggest that lacosamide could be effective in status epilepticus. We report a child with prolonged, refractory status epilepticus that persisted for 10 weeks despite treatment with multiple anti-epileptics and anesthetics and was then aborted with lacosamide. This is the first report of the effect of lacosamide in prolonged refractory status epilepticus, and the first report of lacosamide efficacy in status epilepticus in a child.

• Authors: Yael Shiloh-Malawsky, Zheng Fan, Robert Greenwood, Michael Tennison
• Journal: Seizure (Seizure) Vol. 20 Issue 7 Pg. 586-8 (Sep 2011) ISSN: 1532-2688 [Electronic] England
• PMID: 21474342 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Acetamides
• Anticonvulsants
• Lacosamide

Topics

• Acetamides (therapeutic use)
• Anticonvulsants (therapeutic use)
• Child
• Humans
• Lacosamide
• Male
• Status Epilepticus (drug therapy)
• Treatment Outcome