Short-term exposure to nonylphenol induces pancreatic oxidative stress and alters liver glucose metabolism in adult female rats.

Abstract

Nonylphenol is known to have estrogenic properties and has been reported to cause health hazards to animals and humans. The effects of nonylphenol on pancreas are not clearly elucidated. In this study, we sought to evaluate the effects of nonylphenol on the oxidative status of pancreas and consequential effects of nonylphenol on some of the end points of carbohydrate metabolism in the female rats. Rats were administered nonylphenol orally at the doses of 1.5, 15, and 150 mg/kg of body weight per day for 7 days. After 24 h of last dosing, the animals were sacrificed by cervical dislocation. The activities of pancreatic superoxide dismutase and catalase were significantly decreased with a concomitant increase in the levels of H2O2 and lipid peroxidation. Nonylphenol increased plasma insulin levels with a concomitant decrease in the levels of plasma glucose as compared to the control groups of rats. A dose-dependent increase in the activities of liver hexokinase and phosphofructokinase was recorded along with decreased activity of glycogen phosphorylase in liver. Western blot analysis revealed a significant decrease in the levels of GLUT-2. These results show that nonylphenol causes oxidative stress in pancreas and impairs liver glucose homeostasis.

• Authors: R Jubendradass, Shereen Cynthia D'Cruz, P P Mathur
• Journal: Journal of biochemical and molecular toxicology (J Biochem Mol Toxicol) 2011 Mar-Apr Vol. 25 Issue 2 Pg. 77-83 ISSN: 1099-0461 [Electronic] United States
• PMID: 21472897 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Wiley Periodicals, Inc.

Chemical References

• Blood Glucose
• Glucose Transporter Type 2
• Insulin
• Phenols
• Slc2a2 protein, rat
• nonylphenol
• Hydrogen Peroxide
• Catalase
• Superoxide Dismutase
• Glucose

Topics

• Analysis of Variance
• Animals
• Blood Glucose (analysis)
• Carbohydrate Metabolism
• Catalase (metabolism)
• Female
• Glucose (metabolism)
• Glucose Transporter Type 2 (metabolism)
• Homeostasis
• Hydrogen Peroxide (metabolism)
• Hyperinsulinism (pathology)
• Inactivation, Metabolic
• Insulin (blood)
• Lipid Peroxidation (drug effects)
• Liver (drug effects, enzymology, physiopathology)
• Organ Size (drug effects)
• Oxidative Stress
• Pancreas (drug effects, enzymology, physiopathology)
• Phenols (pharmacokinetics, toxicity)
• Rats
• Rats, Wistar
• Superoxide Dismutase (metabolism)