Abstract | BACKGROUND/AIMS: METHODS: Four groups of experimental rats were subcutaneously injected with sesamol (0, 1, 3, or 10 mg/kg) and then, 2 h later, intraperitoneally injected with isoproterenol (100 mg/kg 24 h apart on 2 consecutive days) to induce myocardial infarction. Control rats were treated with saline only. Blood pressure (BP), heart rate (HR), and electrocardiography (ECG) wave durations, serum creatine phosphokinase isoenzymes (CKMB), lactate dehydrogenase (LDH), myocardial histology, MMP-2, and MMP-9 were assessed 24 h after the last dose of isoproterenol was given. RESULTS: BP was lower, and HR, ECG wave durations, CKMB, LDH, myocardial injury, MMP-2, and MMP-9 levels were higher in experimental rats than in control rats. BP was significantly higher, and all the other parameters were significantly lower in the rats treated with sesamol than in those treated with isoproterenol only. CONCLUSIONS:
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Authors | Srinivasan Periasamy, Fan-E Mo, Shin-Yi Chen, Chih-Ching Chang, Ming-Yie Liu |
Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
(Cell Physiol Biochem)
Vol. 27
Issue 3-4
Pg. 273-80
( 2011)
ISSN: 1421-9778 [Electronic] Germany |
PMID | 21471716
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Antioxidants
- Benzodioxoles
- Matrix Metalloproteinase Inhibitors
- Phenols
- sesamol
- L-Lactate Dehydrogenase
- Creatine Kinase, MB Form
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Isoproterenol
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Topics |
- Acute Disease
- Animals
- Antioxidants
(therapeutic use)
- Benzodioxoles
(therapeutic use)
- Blood Pressure
- Creatine Kinase, MB Form
(blood)
- Electrocardiography
- Heart Rate
- Isoproterenol
- L-Lactate Dehydrogenase
(metabolism)
- Male
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Matrix Metalloproteinase Inhibitors
- Myocardial Infarction
(chemically induced, drug therapy, physiopathology)
- Phenols
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
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